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. 2013 Oct 23;8(10):e77946. doi: 10.1371/journal.pone.0077946

Figure 1. P1736 acts as a potent in vitro insulin sensitizer.

Figure 1

a, Chemical structure of P1736. b, Insulin stimulated glucose uptake in normal adipocytes(empty bar), insulin resistant adipocytes(solid bar) and insulin resistant adipocytes treated with rosiglitazone (bar with stripes). c, Glucose uptake in the dexamethasone - induced insulin resistant adipocytes exposed to vehicle(empty bar) or P1736 (10 µM, solid bar). d, Glucose uptake in the dexamethasone-induced insulin resistant adipocytes exposed to vehicle (empty bar) or metformin (1.0mM, bar with stripes). e, Dose response of P1736 on glucose uptake in dexamethasone - induced insulin resistant adipocytes. Data are expressed as Mean ± SEM. Difference between vehicle and treatment groups were statistically evaluated by t-test., #p<0.01 compared to normal adipocytes, **p<0.01 compared to insulin resistant adipocytes (vehicle).