Table 1. Effect of P1736 on Plasma Glucose and Glucose Uptake in Isolated Soleus Muscles of ob/ob mice.
Compound (mg/kg) | Glucose Uptake in soleus muscle (% Increase) | Plasma Glucose (% Reduction) |
---|---|---|
P1736-05 (1.0) | 70* | 34 |
P1736-05 (5.0) | 67* | 35 |
Metformin (150.0) | 38* | 37 |
Rosiglitazone (5.0) | 147** | 49 |
* p<0.05, **p<0.01 compared to vehicle