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. 2013 Oct 23;8(10):e74123. doi: 10.1371/journal.pone.0074123

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© 2013 Tovar-Lopez et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The device was designed to operate with negative pressure (on-chip sampling), using a single syringe pump. a) Schematic of the variables used to determine the thickness of the blood streams. Different widths of the focused stream () was achieved by changing the hydraulic resistance of the inlet feeder channels. See (Text S1). b) A 3D representation of a device fabricated in PDMS-glass (cover-slip of ). c) Detail of the sampling section. Pc, Pf are the reservoirs from the focused and core stream, Lc and Lf the variables to modulate the thickness of the stream. See (Text S1). d) Detail of the microcontraction (stenosis). e) Assembly of the device, showing that Bovine Serum Albumin was used to prevent unspecific adhesion of platelets to the glass surface. f) Schematic of the implemented valve to assist the purging of the device.

Inline graphic — The device was designed to operate with negative pressure (on-chip sampling), using a single syringe pump. a) Schematic of the variables used to determine the thickness of the blood streams. Different widths of the focused stream () was achieved by changing the hydraulic resistance of the inlet feeder channels. See (Text S1). b) A 3D representation of a device fabricated in PDMS-glass (cover-slip of ). c) Detail of the sampling section. Pc, Pf are the reservoirs from the focused and core stream, Lc and Lf the variables to modulate the thickness of the stream. See (Text S1). d) Detail of the microcontraction (stenosis). e) Assembly of the device, showing that Bovine Serum Albumin was used to prevent unspecific adhesion of platelets to the glass surface. f) Schematic of the implemented valve to assist the purging of the device.