Table 3. Representative transcripts regulated by Fsh independently of Δ4-steroid production.
| Gene Symbol | Gene description | Lh regulation1 | Testicular expression profile2 | In vivo androgen response3 |
| Genes up-regulated by Fsh | ||||
| hsd3b1 | 3-HSD 1 protein | Yes | Somatic Down stage 8 | Down |
| hmgcr | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | - | - | - |
| aplp1 | Amyloid-like protein 1 precursor | - | - | - |
| angptl7 | Angiopoietin-related protein 7 Precursor | - | Gonia A | Down |
| abca1 | ATP-binding cassette sub-family A member 1 | No | Somatic | - |
| ctssb1 | Cathepsin S | No | Somatic Down stage 8 | - |
| ctss | Cathepsin S precursor | No | Somatic | - |
| slc7a3 | Cationic amino acid transporter 3 (CAT-3) | No | - | - |
| ccng1 | Cyclin-G1 | - | - | - |
| eftud1 | Elongation factor Tu GTP-binding domain-containing protein 1 | |||
| ezr | Ezrin (p81) (Cytovillin) (Villin-2) | - | - | - |
| fasn | Fatty acid synthase | - | Somatic Up stage 8 | - |
| fra2 | Fos-related antigen 2 | No | Gonia B | - |
| hgfa | Hepatocyte growth factor activator | - | - | Down |
| hk1 | Hexokinase-1 | - | - | - |
| krt12 | Keratin 12 | No | Somatic Down stage 8 | - |
| galns | N-acetylgalactosamine-6-sulfatase precursor | Yes | - | Up at day 7 |
| odc1 | Ornithine decarboxylase | No | Somatic | - |
| mdka | Midkine-related growth factor (Pleiotrophin related) | No | Somatic | - |
| tac1 | Protachykinin 1 precursor | No | Somatic Up stage 8 | - |
| - | Putative uncharacterized protein | No | Somatic | - |
| psmd1 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | No | - | Up at day 7 |
| rbm47 | RNA-binding protein (FLJ20273), transcript variant 1 | - | - | - |
| rhobtb3 | Rho-related BTB domain-containing protein 3 | - | Somatic | - |
| slc25a4 | Solute carrier family 25 member 43 | Yes | Somatic | - |
| tfpi2 | Tissue factor pathway inhibitor 2 | No | Somatic Down stage 8 | - |
| - | Toxin-1 | Yes | - | - |
Up-regulated genes mostly segregated in Cluster 2 whereas down-regulated genes segregated in Cluster 5. The response to Fsh was further identified as insensitive to trilostane in pairwise comparisons (Limma statistical test, p≤5%). When the information was available, we indicated the response to Lh (1) Sambroni et al., 2013), the testicular expression profile as well as the in vivo regulation by androgens ((2)Rolland et al., 2009 and (3) Rolland et al., 2013). -: not determined.