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. 2013 Oct 23;8(10):e78539. doi: 10.1371/journal.pone.0078539

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© 2013 Akk et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Panel A shows the kinetic scheme used in interpreting our data. Panel B shows an extended scheme incorporating a closed-closed conformational change ("flip") preceeding the channel opening step. In this scheme, A receptor with a closed channel (C) binds 2 molecules of agonist (A) then the receptor enters the flipped state (F) while keeping a closed channel. The channel opens (O) from the flipped state. The scheme is discussed further in the Text.