Table 2. Top five differentially expressed genes compared to 2D.
| Top 5 upregulated genes compared to 2D | Fold change | Top 5 downregulated genes compared to 2D | Fold change | Number of differentially expressed genes, up + down, ≥ 2 fold | |
|---|---|---|---|---|---|
| MG4d | IL8 | 14.5 | CLIC3 | 6.6 | 1842 |
| NCOA7 | 7.4 | LOC100008589 | 5.6 | ||
| HSP90AA1 | 5.9 | CLDN7 | 5.5 | ||
| NUFIP2 | 5.8 | ITGB4 | 5.4 | ||
| CSE1L | 5.8 | WNT5B | 5.2 | ||
| MG7d | IL8 | 9.6 | LOC100008589 | 6.0 | 2104 |
| RIOK3 | 7.1 | ID1 | 5.9 | ||
| TTC3 | 6.9 | GPRC5A | 5.8 | ||
| FOSB | 6.7 | NDUFB9 | 5.7 | ||
| EIF3E | 6.5 | SFN | 5.0 | ||
| PH4d | MX1 | 25.6 | KISS1 | 13.8 | 755 |
| IFIT1 | 24.6 | AXL | 12.7 | ||
| OAS2 | 22.7 | WNT5B | 10.8 | ||
| IFI27 | 15.2 | MARCH4 | 10.6 | ||
| STAT1 | 13.0 | FJX1 | 6.5 | ||
| PH7d | HLA-B | 35.2 | AXL | 16.6 | 851 |
| OAS2 | 28.8 | KISS1 | 16.2 | ||
| IFI27 | 27.8 | MT1A | 11.2 | ||
| IFIT1 | 24.8 | MARCH4 | 10.8 | ||
| MX1 | 24.3 | MT2A | 10.3 | ||
| Xenograft | VIM | 64.9 | CALB2 | 23.6 | 2428 |
| H19 | 27.9 | ID1 | 17.1 | ||
| COL5A1 | 26.6 | ALDH1A3 | 15.9 | ||
| APOE | 13.6 | LOC100134265 | 15.5 | ||
| IFIT1 | 13.5 | RARRES1 | 13.1 |
Top five up and downregulated genes and their fold changes in relation to 2D expression values. Number of up- and downregulated genes is larger in the xenograft and Matrigel models than in the polyHEMA model.