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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Leukemia. 2013 Apr 23;28(1):118–128. doi: 10.1038/leu.2013.125

Figure 5. Up-regulation of survival gene expression in leukemia cells from TCL1-Tg:p53−/− mice or from CLL patient samples with 17p deletion.

Figure 5

A Mcl-1, Bcl-XL and Bcl-2 protein expression shown by Western blot analysis (cells isolated from 4-month old mice; n=4 per group).

B Mcl-1 mRNA levels in mouse splenocytes and PC cells shown by RT-PCR. *, p<0.05 between groups (n=4 per indicated strain).

C Bcl-XL mRNA levels in mouse splenocytes and PC cells shown by RT-PCR. *, p<0.05 between groups (n=4 per indicated strain).

D Bcl-2 mRNA levels in mouse splenocytes and PC cells shown by RT-PCR. **, p<0.01 between groups (n=4 per indicated strain).

E Mcl-1, Bcl-XL and Bcl-2 protein levels in CLL cells from human CLL patients with or without 17p deletion (4 >70%17p deletion samples: del1-4; 6 17p WT samples: WT1-6).

F Mcl-1, Bcl-XL and Bcl-2 mRNA levels in CLL cells from patients with or without 17p deletion shown by RT-PCR. **, p<0.01 between groups.