Figure 7. Down-regulation of tumor suppressor miR-15a/16-1 in leukemia cells from TCL1-Tg:p53−/− mice or from patient samples with 17p deletion.
A MiR-15a/16-1 expression in mouse splenocytes and PC cells shown by RT-PCR. **, p<0.01 between groups (cells isolated from 4-month old mice; n=4 per group).
B MiR-15a/16-1 expression in CLL cells from human patients with or without 17p deletion shown by RT-PCR. **, p<0.01 between groups (n=5 per group).