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Development of carbamate probes and profiling their reactivity against brain serine hydrolases by competitive ABPP. (a) Structures of parent (R = Cl) and clickable (R = alkyne) carbamate probes with varying leaving groups. (b) In vitro competitive ABPP of mouse brain showing that leaving groups have a significant effect on serine hydrolase reactivity. See also Supplementary Table S1 for calculated IC50 values for MAGL, ABHD6 and FAAH.
