Table 3.
HER2/neu Expression in Gastric Adenocarcinoma Resection Specimens
| Manual Quantitative HER2/neu IHC Score
|
Total | Positive Rate (HER2/neu IHC 3+), % | ||||
|---|---|---|---|---|---|---|
| 0 | 1+ | 2+ | 3+ | |||
| Stagea | ||||||
| IA | 4 | 0 | 0 | 2 | 6 | 33 |
| IB | 3 | 3 | 1 | 0 | 7 | 0 |
| IIA | 2 | 1 | 1 | 1 | 5 | 20 |
| IIB | 1 | 0 | 0 | 0 | 1 | 0 |
| IIIA | 1 | 0 | 0 | 0 | 1 | 0 |
| IIIB | 3 | 0 | 0 | 0 | 3 | 0 |
| IIIC | 1 | 0 | 0 | 0 | 1 | 0 |
| IV | 3 | 0 | 0 | 0 | 3 | 0 |
| Total | 18 | 4 | 2 | 3 | 27 | |
| Intestinalb | 3 | 3 | 0 | 2 | 8 | 25 |
| Diffuseb | 12 | 0 | 1 | 1 | 14 | 7 |
| Mixedb | 3 | 1 | 1 | 0 | 5 | 0 |
| Total | 18 | 4 | 2 | 3 | 27 | |
| Overall cases with HER2/neu overexpression: 3/27 (11%) | ||||||
Abbreviations: HER2/neu, human epidermal growth factor receptor 2; IHC, immunohistochemistry.
a
American Joint Committee on Cancer/International Union Against Cancer tumor-node-metastasis (AJCC/UICC TNM) classification, 7th edition.
b
Lauren classification.