Table 5.
HER2/neu Expression in Esophageal/Gastroesophageal Junction Adenocarcinoma Resection Specimens
| Manual Quantitative HER2/neu IHC Score
|
Total | Positive Rate (HER2/neu IHC 3+), % | ||||
|---|---|---|---|---|---|---|
| 0 | 1+ | 2+ | 3+ | |||
| Stagea | ||||||
| IA | 4 | 3 | 0 | 2 | 9 | 22 |
| IB | 3 | 1 | 0 | 0 | 4 | 0 |
| IIA | 1 | 0 | 0 | 0 | 1 | 0 |
| IIB | 10 | 0 | 0 | 0 | 10 | 0 |
| IIIA | 5 | 1 | 0 | 0 | 6 | 0 |
| IIIB | 0 | 1 | 0 | 1 | 2 | 50 |
| IIIC | … | … | … | … | 0 | … |
| IV | … | … | … | … | 0 | … |
| Total | 23 | 6 | 0 | 3 | 32 | |
| Grade 1 | 4 | 1 | 0 | 1 | 6 | 17 |
| Grade 2 | 6 | 3 | 0 | 2 | 11 | 18 |
| Grade 3 | 13 | 2 | 0 | 0 | 15 | 0 |
| Total | 23 | 6 | 0 | 3 | 32 | |
| Overall cases with HER2/neu overexpression: 3/32 (9%) | ||||||
Abbreviations: HER2/neu, human epidermal growth factor receptor 2; IHC, immunohistochemistry.
a
American Joint Committee on Cancer/International Union Against Cancer tumor-node-metastasis (AJCC/UICC TNM) classification, 7th edition.