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. 2013 Oct 23;33(43):16865–16873. doi: 10.1523/JNEUROSCI.2449-13.2013

Figure 1.

Figure 1.

Inactivation of the plPFC produces a selective attenuation of VTA DA neuron population activity. A, Representation of histological placements of infusion cannulae into the plPFC (squares, ∼50% shown). B, Activating the plPFC with NMDA did not change the number of spontaneously active dopamine neurons firing in the VTA (expressed as cells/track, gray bar) compared with infusion of vehicle (white bar). Inactivating the plPFC with TTX resulted in a significant decrease in the number of spontaneously active dopamine cells in the VTA (black bar). C, D, The firing rate of spontaneously active dopamine cells and the percentage of cells firing in bursts were not affected by infusion of vehicle (white bar), NMDA (gray bar), or TTX (black bar) into the plPFC. Distributions of firing rate (E) and the percentage of burst firing (F) were not affected significantly by infusions of NMDA or TTX (Kolgomorov–Smirnoff test). *p < 0.05 (one-way ANOVA, Holm-Sidak post hoc test). n = 7–10 rats/group; n = 40–66 neurons/group. Data are represented as mean ± SEM.