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The calpain inhibitor prevents dendritic spine loss induced by CRH. A, The 100 nm calpain inhibitor prevented CRH-induced reduction of PSD95-ir puncta. B, The calpain inhibitor abolished the loss of GFP-filled spines. C, Graph showing quantification of PSD95-ir puncta (F(5,264) = 37.21, p < 0.0001; n = 12) and GFP-filled spines (F(5,264) = 65.56, p < 0.0001; n = 12). Scale bars: A, B, 5 μm.
