Fig. 3.

Kaplan-Meier survival (A and B) and BLI (C and D) curves of Tg(Gfap-luc) mice (A and C) and Tg(MoPrP:Gfap-luc)4053 mice (B and D) infected with RML prions and treated with a 110 mg/kg per day concentration of Compd B beginning at 1 dpi. Compd B treatment (gray) extended survival by 90–100 days compared with untreated mice (black). Treatment with Compd B suppressed the BLI signal at 60 days (C), when infected untreated mice showed upregulation, which predicted efficacy of the compound. Mean brain bioluminescence signal expressed as a percentage of the maximum; error bars represent SEM. Bars under each graph indicate the initiation and duration of treatment.