TABLE 3.
Incubation periods for prion-infected mice treated with Compd B
| Mouse Line |
Inoculum |
Dose |
Treatment Started |
Mean Incubation Period ± S.E.M. |
n/n0* |
|---|---|---|---|---|---|
| mg/kg per day | dpi | days | |||
| Tg(Gfap-luc) | RML | 0 | n/a | 108 ± 1 | 8/8 |
| Tg(Gfap-luc) | RML | 110 | 1 | 219 ± 21 | 10/10 |
| Tg(Gfap-luc) | RML | 110 | 60 | 182 ± 9 | 9/9 |
| Tg(Gfap-luc) | RML | 110 | 78 | 163 ± 14 | 9/9 |
| Tg(MoPrP:Gfap-luc)4053 | RML | 0 | n/a | 52 ± 2 | 15/15 |
| Tg(MoPrP:Gfap-luc)4053 | RML | 110 | 1 | 143 ± 7 | 12/12 |
| Tg(MHu2M,M111V,M165V,E167Q)1014 | sCJD | 0 | n/a | 80 ± 1 | 13/13 |
| Tg(MHu2M,M111V,M165V,E167Q)1014 | sCJD | 110 | 1 | 78 ± 1 | 5/5 |
n0, number of inoculated mice; n/a, not applicable.
*
n, number of ill mice.