TABLE 1.
Screening of NIH Clinical Collections I and II for inhibition of AC2 activity
The NIH Clinical Collections I and II (25 µM) were screened for inhibition of PMA-stimulated (50 nM) cAMP accumulation in HEK-hAC2 cells using the Cisbio HTRF cAMP dynamic 2 detection method. The data represent the average percent inhibition of the PMA-stimulated cAMP response from duplicate plates (see Materials and Methods).
| Compound Name | Inhibition |
|---|---|
| % | |
| SKF-83566 | 85 |
| Tranilast | 69 |
| Loratadine | 64 |
| Thioridazine | 58 |
| Duloxetine | 51 |
| Amlexanox | 41 |
| Indatraline | 39 |
| Oxymetholone | 37 |
| Prochlorperazine | 35 |
| Maprotiline | 33 |