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Modulation of wild-type GLIC by novel compounds. Modulation of proton-activated GLIC currents (pH 5.5, ∼EC10) by vehicle (0.1% DMSO, D), 50 μM propofol (P, black, dotted line), or the predicted ligand (50 µM) were determined from 4–15 measurements as indicated at the base of every column. Statistical significance is relative to vehicle, Dunnet’s multiple comparison test, ANOVA (**P ≤ 0.01; ****P ≤ 0.0001).
