Fig. 6.
Effect of propofol and selected compounds from the virtual screen on wild-type (WT) and mutated GLIC receptors activated at the 10% level. (A) Effects of vehicle (DMSO), propofol (P), and selected hit compounds at 10 μM on WT and M205W. (B) Effect of propofol (P) and virtually screened compounds (100 µM) on EC10 responses in GLIC receptors. The results are grouped according to the DMSO concentration present (0.1 or 0.2%), determined by the concentration of the stock used. Statistical significance for mutant versus WT determined by unpaired t test (**P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001), n = 2–9.