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. 2013 Nov;84(5):670–678. doi: 10.1124/mol.113.087692

Fig. 7.

Fig. 7.

Effect of propofol and compounds identified in the virtual screen on GABA responses. (A) Modulation of EC10 GABA responses in recombinant α1β2γ2 GABAA receptors by 50 μM propofol (P) and selected hit compounds. Statistical significance is versus a hypothetical value of 0 (*P ≤ 0.05; **P ≤ 0.01; ****P ≤ 0.0001), one-sample t test, n = 4–12. (B) Effect of mutation N265I in the β2 subunit (NI) on responses to 50 μM propofol and compounds 7 and 22. Statistical significance is versus wild-type (WT) (*P ≤ 0.05; ***P ≤ 0.001), unpaired t test, n = 4–6.