Table A2.
Clinical Characteristics of Patients With Cancer-Predisposing Syndromes
| Predisposing Syndrome | Type of Second Cancer | Sex | Age at ALL (years) | WBC at ALL (×109/L) | BCP or T-Cell ALL | Interval to SMN (years) | Age at SMN (years) | Status | Survival (years) |
|---|---|---|---|---|---|---|---|---|---|
| Down syndrome | AML | Male | 3.2 | 16.8 | B | 4.0 | 7.2 | Dead | 0.8 |
| Down syndrome | AML | Female | 2.0 | 7.8 | B | 5.9 | 7.9 | Dead | 1.1 |
| Down syndrome | Mature B-cell NHL | Male | 6.2 | 38.1 | B | 2.6 | 8.8 | Alive | 7.0 |
| Down syndrome | Ewing sarcoma | Female | 6.6 | 2.1 | B | 8.3 | 14.9 | Alive | 5.4 |
| Li Fraumeni syndrome | AML | Male | 12.4 | 6.6 | B | 2.5 | 15.0 | Dead | 0.6 |
| Ataxia telangiectasia | T-cell NHL | Male | 9.5 | 86.0 | T | 12.5 | 22.0 | Dead | 0.6 |
| Noonan syndrome | MDS | Female | 16.0 | 2.0 | B | 2.7 | 18.7 | N/A | |
| AIDS | Mature B-cell NHL | Male | 13.7 | 1.8 | B | 4.0 | 17.7 | Alive | 10.2 |
Abbreviations: ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; BCP, B-cell precursor; MDS, myelodysplastic syndrome; N/A, not available; NHL, non-Hodgkin lymphoma; SMN, second malignant neoplasm.