Table 4.

CSF marker levels for prediction of intrathecal synthesis of borrelial antibodies and prediction of Borrelia isolation from CSF in patients with clinically evident Lyme neuroborreliosis^c

Cytokine or chemokine	Present vs absent intrathecal synthesis		Positive vs negative culture result
	OR (95% CI)a	P	OR (95% CI)	P
CXCL13	1.004 (1.001–1.006)	0.004b	1 (1–1)	0.33
IL-8	1 (1–1.01)	0.12	1 (1–1)	0.76
IL-1β	1.55 (0.77–3.13)	0.22	0.78 (0.3–2.01)	0.60
IL-6	1 (0.98–1.01)	0.66	1 (0.98–1.02)	0.97
IL-10	1.01 (0.98–1.04)	0.45	1.01 (0.97–1.04)	0.65
IL-12p70	0.94 (0.54–1.63)	0.83	0.97 (0.48–1.96)	0.94
IFN-γ	0.99 (0.95–1.03)	0.53	0.65 (0.44–0.97)	0.03
TNF-α	1.21 (0.97–1.5)	0.09	0.82 (0.62–1.08)	0.16
IL-5	1.01 (0.99–1.03)	0.28	1.01 (0.99–1.02)	0.31
IL-4	1.12 (0.86–1.46)	0.40	0.7 (0.47–1.05)	0.08
IL-2	0.99 (0.96–1.02)	0.50	0.96 (0.84–1.09)	0.53

^aCI, confidence interval.

^bIndicates a statistically significant odds ratio (OR).

^cResults of bivariate logistic regression.