Figure 4.

Maximum-likelihood profiles. (a) Loess-interpolated maximum-likelihood surface of U_c and s from Nelder–Mead-assisted, random grid search. (b) Likelihood profiles for number of canopy mutations U_c, number of background mutations U_b, and the product of U_c and s, the homozygous loss in fitness. (c) Likelihood profiles of the homozygous loss in fitness s, the dominance coefficient h, and hs, the heterozygous loss in fitness. (d) The maximum-likelihood estimate of the product of U_c and s for the indicated values of h and U_b.