Fig 7.

Effect of anti-G protein MAb 131-2G prophylaxis on pulmonary cytokine levels in rA2-line19F RSV-challenged mice. BALB/c mice were challenged with mock-infected tissue culture supernatant (mock) or 1 × 10⁶ TCID₅₀ of rA2-line19F RSV with or without treatment (2 days before challenge) with the intact or F(ab′)₂ form of 131-2G and normal immune globulin (nIgG). Lungs were harvested 8 days p.i., and lung homogenates were tested by Luminex multiplex assay for IL-13 (A), IL-5 (B), IL-4 (C), MCP-1 (D), IP-10 (E), or IL-12 (F). All values are expressed as pg/mg of protein. Data are means ± SEMs. ***, significant difference (P ≤ 0.001; ANOVA) between values for untreated and treated (as indicated) challenged mice. Results are representative of two independent experiments for untreated and 131-2G F(ab′)₂-treated mice. Data for challenge with A2 and for prophylaxis with intact 131-2G are from one experiment.