Table 1.
Correlation of pulmonary virus and antiviral T cell localization with weight loss over timea
| Day | Overall viral load | Virus localization | Overall PVM-specific CTL | Localization of specific CTL | Weight loss |
|---|---|---|---|---|---|
| 7 | ↑↑↑ | Infectious foci around bronchi | (↑) | Around blood vessels in areas of infected bronchi | — |
| 8 | ↑↑ | Scattered throughout the lung parenchyma | ↑ | Interstitium, alveoli in infected areas | ↑ |
| 9 | ↑ | Some areas free of virus | ↑↑ | Interstitium, alveoli in infected and noninfected areas | ↑↑ |
| 10 | (↑) | Increasing areas with T cell clusters free of virus | ↑↑↑ | Interstitium, alveoli in infected and noninfected areas | ↑↑↑ |
| 11 | (↑) | Scattered single infected cells remaining throughout the lung parenchyma | ↑↑ | Scattered throughout the lung parenchyma | ↑↑ |
a
Day, day after virus infection; —, no difference compared to uninfected mice; (↑), minimal increase; ↑, mild increase; ↑↑, moderate increase; ↑↑↑, strong increase.