Fig 1.

rhcmvIL-10 vaccine-induced antibody responses. Four RhCMV-uninfected juvenile macaques were immunized over the course of 26 weeks with a mixture of two different nonfunctional forms of rhcmvIL-10, rhcmvIL-10M1 and -M2, by a DNA prime (solid arrow) and 3 protein boosts (dashed arrows). All animals were challenged with RhCMV at 34 weeks (asterisk). (A) rhcmvIL-10 binding antibodies (Ab). (B) rhcmvIL-10 neutralizing antibodies. (C) Plasma samples from the four vaccinees (V1 to V4) and one control (C1) were evaluated before (−) and after (+) immunization for neutralization of rhcmvIL-10 (white) and cIL-10 (black) functions.Mamu, Macaca mulatta.