Fig 5.

T cell responses to late proteins are primarily mediated by CD8 T cells during latent infection in BAL fluid samples. The frequency of IFN-γ-producing CD4 (black) and CD8 (gray) T cells in BAL fluid in response to immunogenic SVV ORFs was measured by intracellular cytokine staining (ICS) following stimulation with the indicated overlapping peptide pools. (A and B) The average percentages of responding IFN-γ⁺ T cells ± SEM in BAL fluid are shown. (C) Average overall CD4 and CD8 responses to all IE/E and L genes are shown.*, P < 0.05.