Table 1.

HLA-B*57:01, -B*57:03, and -B*58:01 amino acid sequence differences

Residue typea	Antigen	Residue at positionb								Preferred residue atc:
		9	24	45	46	63	66	67	99	P2
Residues determing B pocket	HLA-B*57:01	Y	A	M	A	E	N	M	Y	S/T/A
	HLA-B*57:03	—	—	—	—	—	—	—	—	S/T/A
	HLA-B*58:01	—	—	T	E	—	—	—	—	S/T/A
		77	80	81	94	95	97	114	116	PC
Residues determining F pocket	HLA-B*57:01	N	I	A	I	I	V	D	S	F/W
	HLA-B*57:03	—	—	—	—	—	—	N	Y	F/W
	HLA-B*58:01	—	—	—	—	—	R	—	—	F/W
			103	156	194	282	305	325
Residues not in direct contact with B or F pockets	HLA-B*57:01		V	L	I	V	A	C
	HLA-B*57:03		—	—	—	—	—	—
	HLA-B*58:01		L	—	V	I	T	S

^aBased on reference 17.

^b—, conservation of the residue shown according to the HLA-B*57:01 reference.

^cPeptide residue at position 2 or the C terminus (13, 19).