Table 4.
Characteristics of HIV-specific CD8+ T cells obtained from subject R039 and viral vectors used for HIV infection of target cells
| Characteristic | Result |
|---|---|
| HLA restriction type | HLA-B*57:01 |
| Epitope | KF11 |
| Protein | Gag |
| HXB2 position | 162–172 |
| Viral vectors in NL4-3 and VLP | p83-2 and pCMVR8.2a |
| HIV clade B and C sequence | KAFSPEVIPMF |
| % CD8+ T-cell specificityb | 98.4 |
a
Both vectors contain the KF11 Gag epitope as listed in the Los Alamos database (www.hiv.lanl.gov).
b
Tetramer-positive CD3+ CD8+ gated T cells.