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Comparison of receptor-binding mechanisms of coronavirus S1 C-domains. These C-domains include HCoV-NL63 RBD complexed with human ACE2 (PDB 3KBH), PRCV RBD complexed with porcine APN (4F5C), and SARS-CoV RBD complexed with human ACE2 (2AJF). The arrow represents interaction between the MERS-CoV RBD and human DPP4. RBMs and core structures of coronavirus C-domains are in red and cyan, respectively, and receptors are in green.
