Table 1.
Characteristics of the four Env isolates
| Isolate | Source | Clade | Coreceptor usage | b12 IC50a (μg/ml) | Loop length (no. of aa) |
No. of PNGS |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| V1 | V2 | V3 | V4 | V5 | C1 | V1/V2 | C2 | V3 | C3 | V4 | C4 | V5 | C5 | Total | |||||
| 1157ip | Plasma | C | CCR5b | 0.7c | 21 | 43 | 35 | 28 | 13 | 1 | 6 | 8 | 1 | 3 | 4 | 2 | 2 | 0 | 27 |
| 1084i | Plasma | C | CCR5d | 20e | 16 | 44 | 35 | 21 | 10 | 1 | 6 | 6 | 1 | 3 | 4 | 2 | 1 | 0 | 24 |
| HXB2 | TCLAf | B | CXCR4g | 0.01h | 26 | 40 | 36 | 34 | 11 | 1 | 5 | 8 | 1 | 3 | 4 | 1 | 1 | 0 | 24 |
| SF162 | CSFi | B | CCR5g | <0.01h | 25 | 40 | 35 | 28 | 12 | 1 | 3 | 6 | 1 | 3 | 5 | 1 | 1 | 0 | 21 |
a
The 50% inhibitory concentration of IgG-b12.
b
Data were obtained from reference 25.
c
Data were obtained from reference 102.
d
Data were obtained from reference 44.
e
Data were obtained from reference 103.
f
TCLA, T cell line adapted cells.
g
Data were obtained from reference 101.
h
Data were obtained from reference 104.
i
CSF, cerebrospinal fluid.