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Proposed model of SOMV release based on the proteomic approach. SOMVs are released from OM areas where proteins or protein complexes are underrepresented (red) or from areas with low lytic transglycosylase activity, and they link the OM with the PG or the IM. Therefore, proteins such as PorA, PorB, RmpM, PilQ, Slt, MltA, and MltB are underrepresented in SOMVs. Instead, SOMVs are enriched with other OM proteins such as complement inhibitory proteins and autotransporters (green).
