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. 2013 Sep 24;52(42):7369–7376. doi: 10.1021/bi400780v

Figure 1.

Figure 1

Schematic diagram of the UIM regions in ataxin-3. The boundaries of each UIM region are indicated above the full-length C-terminal construct (UIM_123) for UIM1 (E224–E243), UIM2 (D244–N263), and UIM3 (G331–L349). Other protein constructs that include deletion of UIM3 (UIM_12Δ3), deletion of UIM2 and UIM3 (UIM_1Δ23), or substitutions in the UIM regions (UIM_1–UIM_3) are shown below. Light gray rectangles indicate that the native UIM sequence is present, and dark gray rectangles represent UIM sequences with alanine substitutions. Specific residues substituted with alanine residues are represented in bold text.