Schematic diagram
of the UIM regions in ataxin-3. The boundaries
of each UIM region are indicated above the full-length C-terminal
construct (UIM_123) for UIM1 (E224–E243), UIM2 (D244–N263),
and UIM3 (G331–L349). Other protein constructs that include
deletion of UIM3 (UIM_12Δ3), deletion of UIM2 and UIM3 (UIM_1Δ23),
or substitutions in the UIM regions (UIM_1–UIM_3) are shown
below. Light gray rectangles indicate that the native UIM sequence
is present, and dark gray rectangles represent UIM sequences with
alanine substitutions. Specific residues substituted with alanine
residues are represented in bold text.