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. 2013 Jul 30;19(21-22):2495–2505. doi: 10.1089/ten.tea.2012.0648

FIG. 5.

FIG. 5.

Micro-CT analysis and quantitative measurements of calvarial defects at 2 and 4 weeks. Both the BMSC/BMP2 and BMSC/BMP2/rhPDGF-BB groups showed extensive new bone formation, in which the new bone had low radiopacity at 2 weeks. The new bone at 4 weeks was more mature and had enhanced radiopacity compared to the bone at 2 weeks. Both BMSC/BMP2 and BMSC/BMP2/rhPDGF-BB groups showed significantly higher levels of mineralized BV percentage to TV of defect at 2 and 4 weeks (ANOVA, p=0.026 and p=0.001, respectively). However, there was no significant difference between BMSC/BMP2 and BMSC/BMP2/rhPDGF-BB groups. In terms of BMD, there was no statistical significance at 2 weeks. At 4 weeks, the BMSC/BMP2 group showed significantly less BMD of newly formed bone than other groups, including BMSC/BMP2/rhPDGF-BB groups (ANOVA, p=0.009). *Statistically different from the BMSCs and rhPDGF-BB groups. †Statistically different from the other groups. Micro-CT images: left, coronal section view; middle, transverse view; right, 3D reconstruction of newly formed bone in the defect site; arrow, margin of defect; BV/TV, the percentage of mineralized bone volume of the defect tissue volume; BMD, bone mineral density. Values represent mean±SD of six samples. micro-CT, microcomputed tomography.