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. 2013 May 8;34(8):1049–1056. doi: 10.1002/humu.22337

Figure 2.

Figure 2

A genetic variant in the let-7 promoter may contribute to human height variation. A: Each data point represents a human miRNA and the y-axis shows the log10 of the P value of miRNA target site enrichment among genes implicated in height by GWAS. The dashed line denotes the significance threshold (empirical P = 0.01). B: SNP rs113431232, which is in LD with an index SNP (rs1257763) for height, occurs in a validated E2F4 binding site within the promoter region of the let-7a/d/f miRNA cluster. H3K4me3 (histone H3 lysine 4 tri-methylation) ChIP-seq signal (ENCODE) denotes promoter regions; DNase HS (DNase I hypersensitive site) signal (ENCODE) denotes open chromatin; E2F4 ChIP-seq signal (ENCODE) denotes chromatin occupancy of transcription factor E2F4. Peak E2F4 occupancy signal (red rectangle) occurs within a local dip in the DNase HS signal, which is indicative of a bound transcription factor(s). All ENCODE data shown are from HeLa cells.