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Tolerance profile for sorafenib
| Event | N (%) |
|---|---|
| Overall adverse affects | 42 (89.4%) |
| Median length on medication, months (range) | 5.5 (0.8-26) |
| Number of patients with at least one grade 3/4 adverse affect | 21 (46.8%) |
| Dose reduction | 31 (66%) |
| Temporary drug discontinuation | 19 (40.4%) |
| Permanent drug discontinuation because of adverse effect | 18 (38.3%) |
| Permanent drug discontinuation because of progression of disease and symptomatic progression | 2 (2.1%) |
| Self-discontinuation of medication | 1 (2.1%) |
