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. Author manuscript; available in PMC: 2013 Oct 25.
Published in final edited form as: Immunity. 2004 Feb;20(2):121–131. doi: 10.1016/s1074-7613(04)00024-x

Figure 1. Dendritic Cell Maturation Determines the Fate of Responding CD4+ T Cells.

Figure 1

Immature DCs can induce a number of responses from CD4+ T cells which are conducive to tolerance. These include anergy, apoptosis, or differentiation into a regulatory T cell producing immunosuppressive cytokines such as IL-10. Mature DCs, on the other hand, express elevated levels of costimulatory molecules and secrete proinflammatory cytokines such as IL-12. This allows mature DCs to efficiently prime CD4+ cells to differentiate into Th1 type effector cells secreting IL-2 and IFN-γ.