Fig 5.

P6 is antifibrotic in two models of progressive liver injury. RelA-P-Ser536 staining in fibrotic bands in NASH patients (A); black arrows denote RelA-P-Ser536-stained cells. Quantification of liver Sirius Red staining, α-SMA mRNA expression, and hepatic Oil Red O staining (B) in the MCD diet model. Representative photomicrographs of α-SMA-stained (C) liver sections in the MCD diet model. Quantification of Sirius Red staining in the chronic CCl₄ injury model, hepatic collagen and α-SMA mRNA expression (D), and α-SMA staining in liver sections (E) in the chronic CCl₄ model. Data are expressed as mean ± standard error of the mean of five animals per group.