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. 2013 Apr 5;133(6):1380–1388. doi: 10.1002/ijc.28143

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© 2013 UICC

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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mRNA expression of vitamin D pathway genes differs between colorectal tumors and respective adjacent mucosa. mRNA expression was assessed in colorectal tumors and adjacent mucosa by qRT-PCR. 2-tailed paired t-tests on log transformed data were computed (*p < 0.05, **p < 0.001). Relative expression of CYP24A1 (n = 69) and CYP27B1 (n = 68) are shown in (a), RXR (n = 63) and VDR (n = 68) in (b), CYP3A4 (n = 70) in (c). Median, interquartile range and whiskers representing 5th to 95th percentile are shown. CYP24A1 protein expression in tumors and adjacent mucosa samples was determined by immunofluorescence stainings and was graded from 1–5 (low-high, x-axis), respective mRNA expression of CYP24A1 is shown on the y-axis (d).