Table 2.
Hepatic TCDD Levels and Percentage of Administered Dose
| Time point | Study | TCDD levels in hepatic tissue (ppb) | Percent of administered dosea |
|---|---|---|---|
| Vehicle | 0.0633±0.0555 | NA | |
| 2 h | Boverhof et al. (2005) | 62.267±7.336* | 10.743±1.515 |
| 4 h | 103.833±29.759* | 18.660±3.935 | |
| 8 h | 153.667±40.624* | 24.906±4.025 | |
| 12 h | 135.067±49.900* | 28.078±11.306 | |
| 18 h | 167.667±32.021* | 32.740±7.316 | |
| 24 h | 191.000±86.157* | 47.745±25.694 | |
| 72 h | 213.667±16.197* | 61.577±22.293 | |
| 168 h | 87.533±26.864* | 33.087±10.114 | |
| 1 week | Long term | 143.667±5.132* | 40.269±5.432 |
| 4 weeks | 13.373±3.491* | 4.576±1.175 | |
| 12 weeks | 0.553±0.306 | 0.183±0.094 | |
| 24 weeks | 0.013±0.004 | 0.006±0.002 | |
| 36 weeks | ND | NA | |
| 72 weeks | ND | NA |
Note. Abbreviations: NA, not applicable; ND, not determined, as levels had returned to background.
aPercent of administered dose was calculated as: absolute liver TCDD weight (ng) divided by total TCDD administered per mouse (ng) multiplied by 100%. Total liver ng TCDD is equivalent to TCDD hepatic levels (in ng/g or ppb) × absolute liver weight (in g), whereas total ng TCDD administered per mouse takes into account the TCDD dose (30 μg/kg or ng/g) multiplied by the average mouse weight at the time of dosing (g).
*Significantly different from vehicle, p < .05.