Table 3.

Functional Categorization and Expression of Select Differentially Expressed Genes Following Long-term Exposure to 30 μg/kg TCDD

Functional category	Gene ID	Gene name	Gene symbol	Regulation	1 week	4 weeks	12 weeks	24 weeks	36 weeks	72 weeks	2–168h (Boverhof et al., 2005)a
Oxidoreductase activity/glutathione metabolism	72535	Aldh1b1 aldehyde dehydrogenase 1 family, member B1	Aldh1b1	▲	1.5	1.4	NC	NC	NC	NC	Yes
	109857	Carbonyl reductase 3	Cbr3	▲	1.7	NC	NC	NC	NC	NC	Yes
	13057	Cyba cytochrome b-245, alpha polypeptide	Cyba	▲	1.6	NC	NC	NC	NC	NC	Yes
	12858	Cytochrome c oxidase subunit Va	Cox5a	▲	1.6	NC	NC	NC	NC	NC	Yes
	13076	Cytochrome P450, family 1, subfamily a, polypeptide 1	Cyp1a1	▲	16.3	32.2	3.3	NC	NC	NC	Yes
	14858	Glutathione S-transferase, alpha 2 (Yc2)	Gsta2	▲▼	3.0	1.9	−2.0	NC	NC	NC	Yes
	14860	Glutathione S-transferase, alpha 4	Gsta4	▲	1.8	NC	NC	NC	NC	NC	Yes
	14872	Glutathione S-transferase, theta 2	Gstt2	▲	1.7	NC	NC	NC	NC	NC	Yes
	18104	NAD(P)H dehydrogenase, quinone 1	Nqo1	▲	2.0	1.9	NC	NC	NC	NC	Yes
	99929	TCDD-inducible poly (ADP-ribose) polymerase	Tiparp	▲	5.1	1.6	NC	NC	NC	NC	Yes
	22235	UDP-glucose dehydrogenase	Ugdh	▲	2.1	2.0	NC	NC	NC	NC	Yes
	22436	Xanthine dehydrogenase	Xdh	▲	1.8	1.5	NC	NC	NC	NC	Yes
Lipid metabolism	66082	Abhydrolase domain containing 6	Abhd6	▲▼	2.3	NC	NC	NC	NC	−1.6	Yes
	11430	Acyl-coenzyme A oxidase 1, palmitoyl	Acox1	▲	NC	NC	NC	NC	NC	1.8	No
	11606	Angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Agt	▼	NC	NC	NC	NC	NC	−1.7	Yes
	11806	Apolipoprotein A-I	Apoa1	▼	−2.5	−2.0	NC	NC	NC	NC	Yes
	12491	CD36 antigen	Cd36	▲	4.5	2.5	NC	NC	NC	NC	Yes
	11770	Fatty acid–binding protein 4, adipocyte	Fabp4	▲	1.7	NC	NC	NC	NC	NC	Yes
	16592	Fatty acid–binding protein 5, epidermal	Fabp5	▲	NC	NC	3.7	NC	NC	NC	Yes
	15108	Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10	Hsd17b10	▲	NC	NC	NC	NC	NC	2.0	No
	15446	Hydroxyprostaglandin dehydrogenase 15 (NAD)	Hpgd	▲	1.6	NC	NC	NC	NC	NC	Yes
	15450	Lipase, hepatic	Lipc	▼	−1.5	NC	NC	NC	NC	NC	Yes
	64898	Lipin 2	Lpin2	▲	NC	1.6	NC	NC	1.6	NC	Yes
	16956	Lipoprotein lipase	Lpl	▲	2.3	2.2	NC	NC	NC	NC	Yes
Carbohydrate/glycerol metabolism	225913	Dihydroxyacetone kinase 2 homolog (yeast)	Dak	▼	−2.6	−1.6	NC	NC	NC	NC	Yes
	14718	Glutamate oxaloacetate transaminase 1, soluble	Got1	▼	−1.7	NC	NC	NC	NC	NC	Yes
	14571	Glycerol phosphate dehydrogenase 2, mitochondrial	Gpd2	▼	−2.1	−2.1	NC	NC	NC	NC	Yes
	74182	Glycerophosphocholine phosphodiesterase GDE1 homolog (Saccharomyces cerevisiae)	Gpcpd1	▼	−1.6	NC	NC	NC	NC	NC	Yes
	18534	Phosphoenolpyruvate carboxykinase 1, cytosolic	Pck1	▼	−2.5	NC	NC	NC	NC	NC	Yes
Immune response	12010	Beta-2 microglobulin	B2m	▼	−1.5	NC	NC	NC	NC	NC	Yes
	16149	CD74 antigen	Cd74	▲	2.9	1.5	NC	NC	NC	NC	Yes
	12628	Complement component factor h	Cfh	▼	−1.7	NC	NC	NC	NC	NC	Yes
	14960	Histocompatibility 2, class II antigen A, alpha	H2-Aa	▲	2.9	1.6	NC	NC	NC	NC	Yes
	14961	Histocompatibility 2, class II antigen A, beta 1	H2-Ab1	▲	3.1	NC	NC	NC	NC	NC	Yes
	14969	Histocompatibility 2, class II antigen E beta	H2-Eb1	▲	3.1	1.6	NC	NC	NC	NC	Yes
	14962	Histocompatibility 2, complement component factor B	H2-Bf	▲	2.1	1.8	NC	NC	NC	NC	Yes
	16019	Immunoglobulin heavy constant mu	Ighm	▲	NC	NC	NC	NC	NC	4.1	Yes
	17195	Mannose-binding lectin, serum (C)	Mbl2	▼	−1.7	NC	NC	NC	NC	NC	Yes
DNA and RNA binding/ protein folding/apoptosis	11783	Apoptotic peptidase activating factor 1	Apaf1	▼	NC	NC	NC	NC	NC	−1.7	No
	15505	Heat shock 105kDa/110kDa protein 1	Hsph1	▲	2.0	NC	NC	NC	NC	NC	Yes
	19363	RAD51 homolog B	Rad51b	▼▲	−1.9	−4.6	NC	NC	1.8	NC	Yes
	27367	Ribosomal protein L3	Rpl3	▼	NC	NC	NC	NC	NC	−1.7	No
	212528	tRNA methyltransferase 1	Trmt1	▲	NC	NC	NC	NC	NC	1.7	No

Notes. Abbreviation: Fold changes presented in the table met the filtering criteria of |fold change| > 1.5 and P1(t) > 0.9999. NC, no change.

^aGenes differentially expressed in the Boverhof et al. (2005) data set meeting the filtering criteria of |fold change| > 1.4 and P1(t) > 0.98.