Table 3.
Human Orthologs of CRM Target Proteins Listed in the Reactive Metabolite Target Protein Database
| Entry | Protein name | Gene name | Target proteins having known partners (n = 36) |
|---|---|---|---|
| 1 | P63261 | ACTG1 | Actin, cytoplasmic 2; gamma-actin |
| 2 | P00326 | ADH1C | Alcohol dehydrogenase 1C |
| 3 | P42330 | AKR1C3 | Aldo keto reductase family 1, member C3 |
| 4 | P02768 | ALB | Albumin |
| 5 | P05091 | ALDH2 | Aldehyde dehydrogenase, mitochondrial |
| 6 | P05062 | ALDOB | Aldolase B, fructose-bisphosphate |
| 7 | P05089 | ARG1 | Arginase |
| 8 | A5A6H5 | ATP5A1 | ATP synthase, alpha |
| 9 | P06576 | ATP5B | ATP synthase, beta |
| 10 | P07451 | CA3 | Carbonic anhydrase III |
| 11 | P27797 | CALR | Calreticulin |
| 12 | P04040 | CAT | Catalase |
| 13 | P27487 | DPP4 | Dipeptidyl peptidase IV |
| 14 | P30040 | ERP29 | Endoplasmic reticulum protein 29 |
| 15 | Q05CP7 | FABP1 | Fatty acid–binding protein 1 |
| 16 | P08263 | GSTA1 | Glutathione S-transferase alpha 1 |
| 17 | P09488 | GSTM1 | Glutathione S-transferase Mu-1 |
| 18 | P09211 | GSTP1 | Glutathione S-transferase Pi |
| 19 | Q6PK50 | HSP90AB1 | HSP90B, HSP 84 |
| 20 | Q96GW1 | HSP90B1 | GRP94, tumor rejection antigen 1 |
| 21 | P11021 | HSPA5 | BIP, GRP 78, HSPA5 |
| 22 | P11142 | HSPA8 | Heat shock 70kDa protein 8, Hsc 70 |
| 23 | P10809 | HSPD1 | Heat shock 60 KD protein 1 (chaperonin), HSP-60 |
| 24 | O75874 | IDH1 | Isocitrate dehydrogenase 1 |
| 25 | P07237 | P4HB | Protein disulfide isomerase A1, PDI, Erp59 |
| 26 | P30101 | PDIA3 | Protein disulfide isomerase A3, PDI A3, ER-60 |
| 27 | Q15084 | PDIA6 | Protein disulfide isomerase A6 |
| 28 | P30086 | PEBP1 | Phosphatidylethanolamine-binding protein 1, Raf kinase inhibitor protein |
| 29 | P00558 | PGK1 | Phosphoglycerate kinase 1 |
| 30 | P32119 | PRDX2 | Peroxiredoxin 2 |
| 31 | P30041 | PRDX6 | Peroxiredoxin 6 |
| 32 | Q13228 | SELENBP1 | Selenium-binding protein 1 |
| 33 | P01009 | SERPINA1 | Protease inhibitor 1, Alpha-1-antitrypsin 1-1 |
| 34 | P09493 | TPM1 | Tropomyosin alpha 1 chain |
| 35 | P02766 | TTR | Transthyretin |
| 36 | P10599 | TXN | Thioredoxin |
| Target proteins having no reported partners (n = 16) | |||
| 1 | P49189 | ALDH9A1 | 4-trimethylaminobutyraldehyde dehydrogenase |
| 2 | P60709 | ACTB | Actin, cytoplasmic 1; beta-actin |
| 3 | P06733 | enol | Alpha-enolase |
| 4 | Q9UBR1 | UPB1 | Beta-alanine synthase, ureidopropionase |
| 5 | Q8TDZ9 | CEShBr2 | Brain carboxylesterase hBr2 |
| 6 | P20813 | CYP2B6 | Cytochrome P450 2B6 |
| 7 | P30046 | ddt | D-dopachrome decarboxylase |
| 8 | P68104 | EEF1A1 | Elongation factor 1-alpha 1 |
| 9 | P07099 | ephX1 | Epoxide hydrolase 1 |
| 10 | P16930 | FAH | Beta-diketonase, Fumarylacetoacetase |
| 11 | Q14353 | Gamt | Guanidinoacetate N-methyltransferase |
| 12 | P28330 | acadl | Long-chain-specific acyl-CoA dehydrogenase, mitochondrial |
| 13 | Q02252 | Aldh6a1 | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial |
| 14 | P52758 | Hrsp12 | 14.5kDa translational inhibitor protein, Ribonuclease UK114 |
| 15 | Q00266 | mat1a | S-adenosylmethionine synthase isoform type-1 |
| 16 | Q53HE2 | TPI1 | Triosephosphate isomerase, TIM |