Table 9.
Target Proteins With the Strongest Direct Links to Toxicity
| Target protein name | Gene name | GO-MF | GO-BP | KEGG | Sum | Overall rank | Hit ranka |
|---|---|---|---|---|---|---|---|
| Actin, cytoplasmic 2; gamma-actin | ACTG1 | 41 | 6 | 0 | 47 | 1 | 12 |
| Heat shock 70kDa protein 8, Hsc 70 | HSPA8 | 17 | 8 | 4 | 29 | 2 | 15 |
| HSP90B, HSP 84 | HSP90AB1 | 11 | 8 | 4 | 23 | 3 | — |
| BIP, GRP 78, HSPA5 | HSPA5 | 8 | 8 | 3 | 19 | 4 | — |
| Tropomyosin 1 alpha chain | TPM1 | 10 | 5 | 0 | 15 | 5 | 6 |
| Heat shock 60 KD protein 1 (chaperonin), HSP-60 | HSPD1 | 3 | 8 | 3 | 14 | 6 | 3 |
| Phosphatidylethanolamine-binding protein 1, Raf kinase inhibitor protein | PEBP1 | 4 | 6 | 3 | 13 | 7 | — |
| Thioredoxin | TXN | 2 | 8 | 3 | 13 | 8 | — |
| Calreticulin | CALR | 6 | 6 | 0 | 12 | 9 | 24 |
| Albumin | ALB | 4 | 7 | 0 | 11 | 10 | 4 |
| GRP 94, tumor rejection antigen 1 | HSP90B1 | 1 | 8 | 1 | 10 | 11 | — |
| Dipeptidyl peptidase IV | DPP4 | 2 | 5 | 2 | 9 | 12 | — |
| Glutathione S-transferase Pi | GSTP1 | 0 | 5 | 3 | 8 | 13 | — |
| Protein disulfide isomerase A3, PDI A3, ER-60 | PDIA3 | 2 | 5 | 1 | 8 | 14 | 2 |
| Aldo keto reductase family 1, member C3 | AKR1C3 | 0 | 6 | 0 | 6 | 15 | — |
| Aldehyde dehydrogenase, mitochondrial | ALDH2 | 2 | 4 | 0 | 6 | 16 | — |
| Endoplasmic reticulum protein 29 | ERP29 | 2 | 4 | 0 | 6 | 17 | — |
| Peroxiredoxin 6 | PRDX6 | 3 | 3 | 0 | 6 | 18 | 16 |
| Protease inhibitor 1, Alpha-1-antitrypsin 1-1 | SERPINA1 | 2 | 4 | 0 | 6 | 19 | 22 |
| ATP synthase, alpha | ATP5A1 | 0 | 5 | 0 | 5 | 20 | 23 |
| Protein disulfide isomerase A1, PDI, Erp59 | P4HB | 4 | 1 | 0 | 5 | 21 | 1 |
| ATP synthase, beta | ATP5B | 0 | 4 | 0 | 4 | 22 | 18 |
| Glutathione S-transferase Mu-1 | GSTM1 | 0 | 3 | 1 | 4 | 23 | — |
| Peroxiredoxin 2 | PRDX2 | 0 | 3 | 1 | 4 | 24 | — |
| Transthyretin | TTR | 1 | 2 | 1 | 4 | 25 | — |
| Aldolase B, fructose-bisphosphate | ALDOB | 0 | 3 | 0 | 3 | 26 | — |
| Fatty acid–binding protein 1 | FABP1 | 2 | 1 | 0 | 3 | 27 | 27 |
| Phosphoglycerate kinase 1 | PGK1 | 0 | 3 | 0 | 3 | 28 | — |
Note. The ranking is based on taking PPIs into account as described in the text and in Figure 1. The overall rank is based on the sum of the KEGG, GO-BP, and GO-MF rankings (Tables 4, 7 and 8, respectively). The ranking by number of hits given in Table 2 is repeated here for comparison.
aHit rank scores are from Table 2.