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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Biochem Pharmacol. 2013 Aug 18;86(7):10.1016/j.bcp.2013.08.013. doi: 10.1016/j.bcp.2013.08.013

Fig. 8.

Fig. 8

Representative chromatograms depicting metabolism of dapivirine by colon and vagina tissue biopsies. Biopsies were incubated with dapivirine (10 μM) for 24 hours at 37 °C. After incubation, the medium was collected and biopsies were homogenized in ethyl acetate. Medium and homogenates were analyzed via uHPLC-MS/MS in selected reaction monitoring mode. A. Colon 3 biopsy medium. B. Colon 3 biopsy in situ. C. Vagina 3 biopsy medium. D. Vagina 3 biopsy in situ.