Table 1.
Amyloid Growth Parameters
| Protein | SERF1a | tm | tl | kapp |
|---|---|---|---|---|
| aSyn | − | 50.51 ± 3.19 hr | 21.94 ± 7.57 hr | 0.07 ± 0.014 hr−1 |
| + | 13.5 ± 1.37 hr | 10.94 ± 3.50 hr | 0.39 ± 0.076 hr−1 | |
| httQ53Ex1 | − | 81.00 ± 0.04 min | 20.35 ± 0.06 min | 0.036 ± 3.09 × 10−5 min−1 |
| + | 56.27 ± 0.35 min | 9.76 ± 0.42 min | 0.043 ± 2.96 × 10−4 min−1 | |
| Aβ40 | − | 12.99 ± 2.73 hr | 11.35 ± 5.97 hr | 0.28 ± 0.08 hr−1 |
| + | 1.58 ± 0.133 hr | 0.47 ± 0.169 hr | 1.79 ± 0.14 hr−1 | |
| PrP | − | 10.89 ± 0.13 hr | 8.33 ± 0.88 hr | 0.78 ± 0.07 hr−1 |
| + | 3.70 ± 0.13 hr | 1.99 ± 0.47 hr | 1.17 ± 0.2 hr−1 |
Amyloid growth kinetic parameters for proteins used in this study in the absence and in the presence of SERF1a: midpoint of amyloid growth, tm; initial lag phase, tl; apparent rate of amyloid formation, kapp. The values are mean averages, including the SEM of three independent measurements.