Fig. 7.

Deletion of Sox2 results in reduced number of Merkel cells. (A, B) Immunofluorescence labelling of Merkel cells with antibody to K8 in back skin wholemounts of K14CreSox2fl/− (A) and K14CreSox2fl/fl (B) mice, visualised from the epidermal side. (C) Quantification of number of touch domes per area (microscopic field) of back skin (n=4 biological replicates). (D) Quantification of guard hair number per area (microscopic field) of back skin (n=4 biological replicates). (E) Quantification of number of K8+ Merkel cells/per touch dome (n=7 biological replicates, 30 touch domes per replicate). Scale bars: 50 μm.