Table 1. Association of rs59335482 with BIN1 mRNA level in brain and in lymphoblasts (Hapmap 3).
| rs59335482 | DD | ID | II | P-value |
|
|---|---|---|---|---|---|
| Model 1 | Model 2 | ||||
| BIN1 mRNA level | |||||
| Whole (n=125) | 1.7±1.4 | 2.3±2.2 | 2.6±1.8 | 0.02 | 0.01 |
| Controls (n=61) | 1.2±0.5 | 1.3±0.6 | 1.7±0.7 | 0.17 | 0.07 |
| Cases (n=64) | 2.3±1.9 | 3.2±2.7 | 3.2±2.7 | 0.15 | 0.11 |
| Hapmap3a (n=98) | 10.8±0.9 | 11.1±0.7 | 11.3±0.7 | 0.02 | 0.01 |
Abbreviations: D, deletion; I, insertion. Analysis was performed using a non parametric Wilcoxon test following recessive or additive models (respectively model 1 and model 2).
a
Denotes populations imputed for the rs59335482.