Table 2. Association of rs59335482 with pathological hallmark lesions in AD brains.
| rs59335482 | DD (n=31) | ID (n=30) | II (n=6) | P-value |
|
|---|---|---|---|---|---|
| Model 1 | Model 2 | ||||
| Pathological hallmarks of AD | |||||
| Tau Loads | 2.5±2.7 | 4.6±4.2 | 5.7±3.2 | 0.03 | 0.009 |
| Aβ40 loads | 3.2±3.2 | 3.9±4.2 | 4.1±3.8 | 0.70 | 0.40 |
| Aβ42 Loads | 10.3±4.3 | 9.7±3.9 | 8.4±3.3 | 0.55 | 0.40 |
Abbreviations: AD, Alzheimer's disease; D, deletion; I, insertion.
Analysis was performed using a non parametric Wilcoxon test following recessive or additive models (respectively model 1 and model 2).