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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Biomaterials. 2013 Jul 27;34(33):10.1016/j.biomaterials.2013.07.038. doi: 10.1016/j.biomaterials.2013.07.038

Table 2.

Docetaxel pharmacokinetic parameters of 9%-NP and 20%-NP

Specimen Parameter Formulation
9%-NP 20%-NP
Plasma AUC (ng/mL h) 95,692 (0–72 h) 82,743 (0–72 h)
Cmax (ng/mL) 19,583 ± 7,997 26,753 ± 5,603
CL (mL/h/kg) 105 121
Vd (mL/kg) 943 1278
T1/2 (h) 6.6 7.4
Tumor AUC (ng/mL h) 99,586 (0–168 h) 71,848 (0–168 h)
Cmax (ng/mL) 1,199 ± 1,115 1038 ± 366
Liver AUC (ng/mL h) 1,080,179 (0–168 h) 1,513,225 (0–168 h)
Cmax (ng/mL) 16,359 ± 11,681 19,274 ± 10,838
Spleen AUC (ng/mL h) 5,282,385 (0–168 h) 6,934,196 (0–168 h)
Cmax (ng/mL) 44,294 ± 26,239 73,061 ± 10,855
Lung AUC (ng/mL h) 165,962 (0–168 h) 258,766 (0–168 h)
Cmax (ng/mL) 17,218 ± 6,347 20,200 ± 2,861