Table 2.

Summary of different medical therapies in laryngopharyngeal reflux disease (LPRD) with proven or uncertain efficacy.

	Medical therapy in LPRD treatment
	Proven	Uncertain
PPI	Double dosage for 12 weeks in patients with laryngeal and typical GERD symptoms	Patients without typical GERD symptoms
H2RA	Useful in add-on therapy in patients with nocturnal acid breakthrough	Alternative to PPI therapy
Prokinetic		Usually considered unhelpful
Alginate	Useful in add-on therapy as mechanical barrier
Neuromodulator Reflux-reducing agent Visceral pain modulator	Baclofen is effective in reducing the total number of refluxes TCA, SSRI are effective in patients with hypersensitive esophagus	Arbaclofen placarbil, lesogaberan (few available data)

GERD, gastroesophageal reflux disease; H2RA, histamine-2 receptor antagonist; PPI, proton pump inhibitor; SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant.