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. Author manuscript; available in PMC: 2013 Oct 25.
Published in final edited form as: Semin Thromb Hemost. 2011 Nov 18;37(5):10.1055/s-0031-1281039. doi: 10.1055/s-0031-1281039

Table 2.

Laboratory studies performed in diagnosis of VWD

Initial workup VWF:Ag, VWF:RCo, FVIII:C, multimers1
If ↓ VWF:RCo/VWF:Ag, abnormal multimers LD-RIPA, VWF:PB, consider sequencing
If ↓ VWF:RCo/VWF:Ag, normal multimers Consider sequencing
If ↓ FVIII:C/VWF:Ag VWF:FVIIIB
If ↓↓ VWF:RCo and VWF:Ag VWFpp, survival studies

Abbreviations: VWF:Ag=VWF antigen; VWF:RCo=VWF ristocetin cofactor activity; FVIII:C=factor VIII activity; multimers=multimer distribution analysis; LD-RIPA=low dose ristocetin-induced platelet aggregation; VWF:PB=VWF-platelet binding; VWF:FVIIIB=VWF-FVIII binding; VWFpp=VWF propeptide.

1

Repeat VWF:Ag and VWF:RCo to confirm low levels